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Related Experiment Video

Updated: May 15, 2026

Simple Continuous Glucose Monitoring in Freely Moving Mice
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Published on: February 24, 2023

A comparative effectiveness analysis of three continuous glucose monitors.

Edward R Damiano1, Firas H El-Khatib, Hui Zheng

  • 11Department of Biomedical Engineering, Boston University, Boston, MA, USA.

Diabetes Care
|January 1, 2013
PubMed
Summary

The Navigator continuous glucose monitoring (CGM) device demonstrated superior accuracy and reliability compared to the Seven Plus and Guardian devices during closed-loop blood glucose control in type 1 diabetes.

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Simple Continuous Glucose Monitoring in Freely Moving Mice
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Published on: February 24, 2023

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12:08

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Published on: June 11, 2012

Area of Science:

  • Endocrinology
  • Biomedical Engineering
  • Diabetes Technology

Background:

  • Continuous glucose monitoring (CGM) is crucial for managing type 1 diabetes.
  • Closed-loop blood glucose control systems aim to automate glycemic management.
  • Accurate CGM data is essential for effective closed-loop control.

Purpose of the Study:

  • To compare the accuracy, precision, and reliability of three CGM devices.
  • Evaluate CGM performance under closed-loop blood glucose control.
  • Identify the best-performing CGM device for type 1 diabetes management.

Main Methods:

  • Six subjects with type 1 diabetes participated in 51-hour closed-loop experiments.
  • Three CGM devices (Navigator, Seven Plus, Guardian) were worn simultaneously.
  • Paired plasma glucose measurements were compared against CGM readings.

Main Results:

  • Navigator showed the best accuracy with a mean absolute relative difference (MARD) of 11.8%.
  • Seven Plus and Guardian had higher MARDs (16.5% and 20.3%, respectively).
  • Navigator and Guardian offered nearly 100% data reporting, while Seven Plus reported 76%.

Conclusions:

  • Significant differences in CGM device performance were observed.
  • The Navigator CGM device outperformed the Seven Plus and Guardian in accuracy and reliability.
  • Device selection impacts the effectiveness of closed-loop blood glucose control.