Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Amnesia

Amnesia

Amnesia is a condition marked by long-term memory loss, which impairs the ability to recall past events or create new memories.
The severity and duration of memory loss vary depending on the type and underlying cause. Amnesia is classified into two main types: retrograde and anterograde.
Retrograde amnesia is marked by the loss of memories formed before the onset of the condition. Patients may recall distant past events but often forget those occurring shortly before the incident.
Anterograde...

Transient Ischemic Attack l: Introduction

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...

Dissociative Amnesia

Dissociative Amnesia

Dissociative amnesia is a complex psychological condition that manifests as an inability to recall personal information, often tied to traumatic or stressful events. Unlike general amnesia, individuals with this condition retain the ability to perform routine activities and procedural tasks, such as operating a phone or navigating public transportation, yet experience profound gaps in autobiographical memory. These lapses may encompass significant life events, such as suicide attempts or...

Traumatic Brain Injury l: Introduction

Traumatic Brain Injury l: Introduction

DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...

Traumatic Memory

Traumatic Memory

Emotionally traumatic events often lead to memories that are exceptionally vivid and enduring, sometimes persisting with remarkable clarity throughout an individual's life. A classic example of this phenomenon is a person who survives a car accident. Even years later, they may recall every detail of the event with startling accuracy — the screeching of the tires, the jarring impact, and the acrid smell of burning rubber. Such vividness contrasts sharply with how an individual remembers mundane...

Higher Mental Functions of Brain: Learning and Memory

Higher Mental Functions of Brain: Learning and Memory

Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or playing an...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Lecanemab appropriate use recommendations for clinical practice in the UK.

Journal of neurology, neurosurgery, and psychiatry·2025

Same author

Valedictory Interim Editorial: 'Probabilistic history'.

Journal of medical biography·2025

Same author

Interim editorial.

Journal of medical biography·2025

Same author

Phantasia, aphantasia, and hyperphantasia: Empirical data and conceptual considerations.

Neuroscience and biobehavioral reviews·2024

Same author

Liminality analysis: A conceptual framework applicable to medical biography?

Journal of medical biography·2024

Same author

Medical biography: A symbiotic methodology?

Journal of medical biography·2023

Search research articles

Related Experiment Video

Updated: May 15, 2026

A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury

A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury

Published on: June 20, 2017

Familial transient global amnesia.

R Rhys Davies¹, A J Larner

¹Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Liverpool, UK.

Case Reports in Neurology

|January 1, 2013

Summary

Familial transient global amnesia (TGA) is rare, with few documented cases. This study highlights a patient with affected maternal aunts, suggesting TGA may occur in more distant relatives than previously reported.

Area of Science:

Neurology
Genetics
Epidemiology

Background:

Transient global amnesia (TGA) is a distinct neurological condition characterized by sudden, temporary memory loss.
While sporadic TGA is relatively common, familial TGA (fTGA) is infrequently reported in scientific literature.
Previous studies on fTGA have primarily documented affected individuals within sibling or parent-child relationships.

Observation:

A female patient experiencing typical TGA reported similar episodes in two maternal aunts.
This observation extends the known familial pattern of TGA beyond immediate relatives.
The patient's family history suggests a potential genetic predisposition or shared environmental factors contributing to TGA.

Findings:

The current literature review revealed a scarcity of documented TGA cases involving relatives beyond parents and siblings.

Keywords:

Familial occurrence Migraine Transient global amnesia

More Related Videos

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

Related Experiment Videos

Last Updated: May 15, 2026

A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury

A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury

Published on: June 20, 2017

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

This case report provides evidence for TGA occurring in more distantly related family members (maternal aunts).

The aetiology of familial TGA remains largely unknown, prompting further investigation into potential genetic or pathophysiological mechanisms.

Implications:

Studying familial TGA cases, including those with extended family involvement, may elucidate the underlying causes of TGA.
A potential link between TGA and migraine pathophysiology is suggested, warranting further research into shared mechanisms.
Understanding the genetic and etiological factors of fTGA could lead to improved diagnostic and therapeutic strategies for TGA patients.