Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Transcytosis of IgG

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...

Acute Kidney Injury II: Pathophysiology

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...

Factors Influencing Drug Absorption: Disease States and Pharmacology

Factors Influencing Drug Absorption: Disease States and Pharmacology

Multiple disease states can significantly influence the oral drug absorption process by affecting blood flow and the functionality of the gastrointestinal (GI) system. Various GI diseases, including conditions that alter GI motility, such as diarrhea, decreased acid secretions (achlorhydria), and infections, have been associated with reduced drug absorption.
Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...

Drug Absorption: Factors Affecting GI Absorption

Drug Absorption: Factors Affecting GI Absorption

The process of oral drug absorption can be influenced by several factors. Weakly acidic drugs tend to be absorbed more readily from the stomach due to their nonionized state. However, absorption may be less efficient in the upper intestine, where drugs are often ionized. Interestingly, despite the stomach's apparent advantage for drug absorption, its mucous layer can hinder diffusion. Its surface area is also smaller than the intestine's, which can further slow down the absorption rate.
In...

Inflammatory Bowel Disease II: Ulcerative Colitis

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...

Drug Elimination by Renal Route: Tubular Secretion

Drug Elimination by Renal Route: Tubular Secretion

Once the process of glomerular filtration is completed, blood carrying unfiltered drug molecules traverses through efferent arterioles and makes its way into the peritubular capillaries in the proximal tubule. A variety of carriers play a pivotal role in actively secreting drugs from these peritubular capillaries into the tubular fluid. The organic anion transporter transfers acidic drugs, against an electrochemical gradient, from the peritubular capillaries into the renal tubule cells and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Does stigma curvature promote delayed selfing? An experimental investigation in Triodanis perfoliata (Campanulaceae).

Plant biology (Stuttgart, Germany)·2017

Same author

Comparative pathogenicity of reniform nematode on root-knot resistant and susceptible bidi tobacco.

Journal of parasitic diseases : official organ of the Indian Society for Parasitology·2016

Same author

Estimation of loss and analysis of nicotine, reducing sugar and chloride in bidi tobacco due to reniform nematode under pot conditions.

Journal of parasitic diseases : official organ of the Indian Society for Parasitology·2016

Same author

Role of miRNAs and alternative mRNA 3'-end cleavage and polyadenylation of their mRNA targets in cardiomyocyte hypertrophy.

Biochimica et biophysica acta·2016

Same author

APOE*E2 allele delays age of onset in PSEN1 E280A Alzheimer's disease.

Molecular psychiatry·2015

Same author

Executive summary and conclusions from the European Hydration Institute Expert Conference on human hydration, health, and performance.

Nutrition reviews·2015

Search research articles

Related Experiment Video

Updated: May 15, 2026

An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance

An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance

Published on: December 3, 2020

Gut permeability in IgA nephropathy.

L Layward¹, J M Hattersley, H R Patel

¹Department of Nephrology, Leicester General Hospital, Leicester, UK.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association

|January 2, 2013

Summary

This summary is machine-generated.

This study found no significant difference in gut permeability between patients with IgA nephropathy (IgAN) and controls. Findings do not support the gut permeability hypothesis in IgAN pathogenesis.

More Related Videos

Highly Sensitive Measurement of Glomerular Permeability in Mice with Fluorescein Isothiocyanate-polysucrose 70

Highly Sensitive Measurement of Glomerular Permeability in Mice with Fluorescein Isothiocyanate-polysucrose 70

Published on: August 9, 2019

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice

Published on: July 8, 2020

Related Experiment Videos

Last Updated: May 15, 2026

An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance

An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance

Published on: December 3, 2020

Highly Sensitive Measurement of Glomerular Permeability in Mice with Fluorescein Isothiocyanate-polysucrose 70

Highly Sensitive Measurement of Glomerular Permeability in Mice with Fluorescein Isothiocyanate-polysucrose 70

Published on: August 9, 2019

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice

Published on: July 8, 2020

Area of Science:

Gastroenterology
Nephrology
Immunology

Background:

IgA nephropathy (IgAN) is a kidney disease characterized by IgA deposition in glomeruli.
A hypothesis suggests increased gut permeability may lead to antigen absorption and IgAN.
Assessing gut permeability is crucial for understanding IgAN pathogenesis.

Purpose of the Study:

To investigate the role of gut permeability in IgA nephropathy.
To determine if patients with IgAN exhibit altered small molecule absorption compared to healthy controls.

Main Methods:

Differential absorption of cellobiose and mannitol was measured.
Urinary cellobiose:mannitol excretion ratio was calculated in 18 IgAN patients and controls.

Main Results:

No significant difference in the urinary cellobiose:mannitol ratio was observed between IgAN patients and controls (P = 0.42).
One patient with the highest ratio experienced macroscopic hematuria post-testing, suggesting potential transient gut permeability changes.

Conclusions:

The study does not support the hypothesis that chronic increased gut permeability is a major factor in IgAN.
Transient gut permeability abnormalities may warrant further investigation in specific IgAN cases.