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Resolution of complex ends by Nonhomologous end joining - better to be lucky than good?

Natasha Tiffany Strande1, Crystal Ann Waters, Dale A Ramsden

  • 1Lineberger Comprehensive Cancer Center, Department of Biochemistry and Biophysics and Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA. dale_ramsden@med.unc.edu.

Genome Integrity
|January 2, 2013
PubMed

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Homologous Recombination

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Homologous Recombination02:31

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The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the back-up in case the other strand is damaged. Second, the double-helical structure can be wrapped around proteins called histones to form nucleosomes, which can then be tightly wound to form chromosomes. This way, DNA chains up to 2 inches long can be contained within microscopic structures in a cell. A double-stranded break not only damages...
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Overview