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Updated: May 15, 2026
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Mouse Round Spermatid Injection
Published on: January 26, 2024
Intracytoplasmic morphologically selected sperm injection (IMSI) after repeated IVF or ICSI failures: a prospective
Lucie Delaroche1, Chadi Yazbeck, Clémence Gout
1Department of Obstetrics, Gynaecology and Reproductive Medicine, Bichat-Claude Bernard University Hospital, Paris, France.
Summary
Intracytoplasmic morphologically selected sperm injection (IMSI) improves embryo quality and blastocyst yield in couples with recurrent in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) failures. This technique offers better outcomes after multiple treatment attempts.
Area of Science:
- Reproductive Medicine
- Embryology
- Infertility Treatment
Background:
- Sperm morphology is crucial for successful assisted reproductive technologies.
- Previous in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) failures indicate a need for alternative strategies.
- High implantation rates are associated with optimal sperm morphology.
Purpose of the Study:
- To assess the efficacy of intracytoplasmic morphologically selected sperm injection (IMSI) in patients experiencing repeated IVF or ICSI failures.
- To compare embryo quality and blastocyst development between IMSI and conventional IVF/ICSI cycles.
Main Methods:
- A prospective study involving 75 infertile couples with at least two prior IVF or ICSI failures.
- Couples served as their own controls, undergoing both conventional IVF/ICSI and IMSI.
- Primary outcome measures included embryo quality and the number of blastocysts obtained.
Main Results:
- IMSI cycles yielded a significantly higher percentage of top-quality day 2 embryos (89.8% vs. 79.8%).
- Extended embryo culture to blastocyst stage was more frequent in IMSI cycles (41.3% vs. 26.7%).
- A higher mean number of blastocysts was achieved with IMSI (1.5 vs. 1.0), with clinical pregnancy and birth rates of 29.3% and 18.6% respectively.
Conclusions:
- Intracytoplasmic morphologically selected sperm injection (IMSI) demonstrates improved embryo quality and increased blastocyst production following multiple IVF/ICSI failures.
- IMSI facilitates more embryo transfers at the blastocyst stage, enhancing treatment potential.
- Sperm ultramorphology examination via IMSI is a valuable tool for couples with recurrent IVF/ICSI setbacks.
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