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A pilot randomized controlled trial with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation
Jennifer C Naylor1, Trygve R Dolber, Jennifer L Strauss
1VA Mid-Atlantic Mental Illness, Research and Clinical Center, Durham, NC, USA.
Abstract:
Subthreshold posttraumatic stress disorder (PTSD) is associated with increased risk for suicidality, depression, and functional impairment. We thus conducted a small (N=12) pilot randomized controlled trial (RCT) with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) era veterans. Hospital Anxiety and Depression Scale (HADS) scores improved by 30.4% in the paroxetine group. Paroxetine may have promise for subthreshold PTSD.
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