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Human monoclonal antibodies in cancer therapy: a review of recent developments

Lin Xin1, Jiaqing Cao, Hua Cheng

  • 1Department of General Surgery, The Second Affiliated Hospital of NanChang University, 330006 Nanchang, Jiangxi, China. xinlindoc@yeah.net

Frontiers in Bioscience (Landmark Edition)
|January 2, 2013
PubMed

Insights

Phage-display technology has advanced, enabling the creation of human monoclonal antibodies (mAbs) for cancer therapy. These novel mAbs target various tumor antigens, showing promise in treating advanced solid tumors.

Area of Science:

  • Biotechnology
  • Immunology
  • Oncology

Background:

  • Phage-display technology has seen significant advancements in the past decade.
  • This technology is crucial for generating therapeutic monoclonal antibodies (mAbs).

Purpose of the Study:

  • To highlight the progress in human monoclonal antibody generation using phage display.
  • To review the application of these antibodies in cancer therapy.

Main Methods:

  • Utilizing phage-display technology for antibody generation.
  • Identifying and targeting tumor-specific antigens.
  • Evaluating safety, pharmacokinetics, and pharmacodynamics in clinical settings.

Main Results:

  • Generation of novel human mAbs against diverse cancer targets.
  • Targets include antigens related to apoptosis, angiogenesis, and tumor growth.
  • Clinical evaluation of several human mAbs in patients with advanced solid tumors.

Conclusions:

  • Significant progress has been achieved in human mAb generation and application for cancer treatment.
  • Phage-display technology continues to be a powerful tool in developing targeted cancer therapies.

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