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STIM1 and Orai in cardiac hypertrophy and vascular proliferative diseases

Anne-Marie Lompre1, Ludovic Benard, Ypuakim Saliba

  • 1Inserm UMRS 956, Faculte de Médecine Pitie-salpetriere, Paris, France. anne-marie.lompre@upmc.fr

Frontiers in Bioscience (Scholar Edition)
|January 2, 2013
PubMed

Insights

Stromal interaction molecules (STIM) and Orai proteins are crucial for calcium signaling in the cardiovascular system. Their roles in cardiac hypertrophy and vascular diseases are key areas of ongoing research.

Area of Science:

  • Cardiovascular Biology
  • Molecular Cell Biology
  • Physiology

Background:

  • Cardiac hypertrophy and vascular proliferative diseases involve altered calcium homeostasis.
  • STIM and Orai proteins are critical regulators of calcium signaling.
  • Recent discoveries highlight their potential cardiovascular significance.

Purpose of the Study:

  • To review the existence and function of STIM and Orai proteins in the cardiovascular system.
  • To explore their roles in normal and pathological cardiovascular conditions.
  • To discuss their implications in cardiovascular remodeling.

Main Methods:

  • Literature review of studies on STIM and Orai in the cardiovascular system.
  • Analysis of data concerning calcium signaling pathways.
  • Synthesis of findings related to cardiovascular diseases.

Main Results:

  • STIM and Orai proteins are present and functional in cardiovascular cells.
  • These proteins play significant roles in calcium influx and regulation.
  • Evidence links their dysregulation to cardiac hypertrophy and vascular proliferation.

Conclusions:

  • STIM and Orai are integral to cardiovascular calcium signaling.
  • Their involvement in disease pathogenesis warrants further investigation.
  • Targeting STIM/Orai pathways may offer therapeutic strategies for cardiovascular remodeling.

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