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Bilateral retinoblastoma: clinical presentation, management and treatment

Francesco Pichi1, Andrea Lembo, Mariacarla De Luca

  • 1San Giuseppe Hospital, University Eye Clinic, Via San Vittore 12, 20123, Milan, Italy, ilmiticopicchio@gmail.com.

International Ophthalmology
|January 2, 2013
PubMed

Insights

Bilateral retinoblastoma (Rb) in a 4-month-old girl was successfully managed. Group D Rb in the right eye responded to chemotherapy, while Group E Rb in the left eye required enucleation.

Area of Science:

  • Ophthalmology
  • Pediatric Oncology
  • Medical Genetics

Background:

  • Retinoblastoma (Rb) is the most common intraocular malignancy in childhood.
  • Management is individualized based on tumor classification and patient condition.
  • Bilateral leukocoria necessitates prompt evaluation for retinoblastoma.

Observation:

  • A 4-month-old girl presented with bilateral leukocoria, indicative of retinoblastoma.
  • Right eye: Group D Rb with vitreous seeds and retinal detachment, treated with ICE chemotherapy.
  • Left eye: Group E Rb with total retinal detachment and secondary glaucoma, treated with enucleation.

Findings:

  • Chemotherapy (ICE protocol) led to regression of Group D retinoblastoma with calcification.
  • Enucleation was necessary for Group E retinoblastoma due to extensive disease and glaucoma.
  • Successful management highlights the importance of early detection and tailored treatment strategies.

Implications:

  • Retinoblastoma is curable when detected early and treated appropriately.
  • Multidisciplinary collaboration among ocular oncologists, pediatricians, and ophthalmologists is crucial.
  • Individualized treatment based on International Classification of Retinoblastoma improves outcomes.

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