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The association between CD14 gene C-260T polymorphism and coronary heart disease risk: a meta-analysis

Hong Pu1, Jiong Yin, Yan Wu

  • 1Department of Cardiology, The 85th Hospital of PLA, 1328 Huashan Road, Shanghai, 200052, People's Republic of China. hong_pu@126.com

Molecular Biology Reports
|January 2, 2013
PubMed

Insights

The CD14 C-260T gene polymorphism increases the risk of coronary heart disease (CHD). This genetic risk factor is particularly significant in East Asian populations, warranting further large-scale studies for confirmation.

Area of Science:

  • Genetics
  • Cardiovascular Disease Epidemiology
  • Molecular Biology

Background:

  • Monocyte differentiation antigen CD14 plays a key role in inflammatory responses linked to atherosclerosis, coronary heart disease (CHD), and myocardial infarction (MI).
  • A common polymorphism in the CD14 gene promoter, C-260T, has shown inconsistent associations with CHD risk.
  • Lipopolysaccharides (LPS) bind to CD14, triggering inflammatory pathways relevant to cardiovascular health.

Purpose of the Study:

  • To conduct a comprehensive meta-analysis investigating the association between the CD14 C-260T gene polymorphism and CHD susceptibility.
  • To resolve inconsistencies in previous studies regarding the genetic contribution of CD14 to CHD.
  • To evaluate the impact of ethnicity on the relationship between CD14 C-260T polymorphism and CHD.

Main Methods:

  • Meta-analysis of 28 independent studies, encompassing 13,335 CHD cases and 7,979 controls.
  • Statistical analysis using random effects models to calculate overall and stratified odds ratios (OR) for the T allele and different genetic models (dominant, recessive).
  • Stratification by ethnicity, sample size, CHD endpoints, and Hardy-Weinberg equilibrium (HWE) status to assess heterogeneity and refine findings.

Main Results:

  • An overall increased risk for CHD was associated with the CD14 C-260T polymorphism (T allele OR = 1.24, P < 10(-5)).
  • Significant associations were observed across dominant (OR = 1.34) and recessive (OR = 1.25) genetic models.
  • Heterogeneity was substantially reduced after stratification by ethnicity, with significant associations found specifically in East Asians, but not in Caucasians or other groups.

Conclusions:

  • The CD14 C-260T polymorphism represents a significant genetic risk factor for coronary heart disease (CHD).
  • The association is particularly pronounced in East Asian populations, highlighting ethnic-specific genetic influences on CHD.
  • Further large-scale epidemiological studies are recommended to validate these findings and elucidate the underlying mechanisms.

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