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Trachea

Trachea

The trachea, commonly known as the windpipe, is a vital part of the human respiratory system. It serves as a passageway for air to travel between the larynx and the bronchi, allowing oxygen to reach the lungs. Let's explore its anatomical features, dimensions, layers of the tracheal wall, associated muscles, and the functions of its parts.
Anatomical Features:
Location: About half of the trachea is situated in the neck, anterior to the esophagus, and extends from the larynx (at the level of the...

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Related Experiment Video

Updated: May 15, 2026

Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model

Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model

Published on: April 1, 2019

Tracheal tissue engineering: building on a strong foundation.

Svenja Hinderer¹, Katja Schenke-Layland

¹Department of Thoracic, Cardiac and Vascular Surgery, University Hospital and Inter-University, Centre for Medical Technology Stuttgart-Tübingen, Eberhard-Karls-University Tübingen, 72076 Tübingen, Germany.

Expert Review of Medical Devices

|January 3, 2013

Summary

Tissue-engineered tracheal transplants offer a novel solution for severe airway disorders, potentially saving lives in pediatric patients. This approach uses a patient's own stem cells to regenerate airway tissue, avoiding complications from traditional methods.

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Last Updated: May 15, 2026

Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model

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Published on: March 8, 2011

Area of Science:

Regenerative Medicine
Biomaterials Science
Pediatric Surgery

Background:

Advanced structural disorders of the large airway, such as laryngotracheal agenesis or severe stenosis, pose life-threatening risks, particularly in pediatric patients.
Current surgical interventions like slide tracheoplasty carry risks including stent erosion and mortality.
Tissue-engineered tracheal constructs present a promising alternative, drawing on successful applications in bladder repair and adult tracheal replacement.

Discussion:

A 2-year follow-up study explored the implantation of an allogeneic, decellularized trachea in a pediatric patient.
The construct was supported by an absorbable polydioxanone stent and seeded with autologous bone marrow-derived stem cells.
This highlights the potential of combining decellularized allografts with patient-specific stem cells for airway reconstruction.

Key Insights:

The study demonstrates the feasibility of using a tissue-engineered trachea in a pediatric setting.
Autologous stem cell seeding enhances the potential for tissue integration and regeneration.
The use of an absorbable stent provides temporary structural support during healing.

Outlook:

Further research and clinical trials are needed to validate long-term efficacy and safety.
This approach could revolutionize the treatment of congenital and acquired large airway defects in children.
Advancements in biomaterials and stem cell technology will likely improve outcomes for tissue-engineered airway replacements.