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Isolation and Profiling of Human Primary Mesenteric Arterial Endothelial Cells at the Transcriptome Level
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Published on: March 14, 2022

Themed section: endothelin.

Anthony P Davenport, Matthias Barton

    British Journal of Pharmacology
    |January 3, 2013
    PubMed
    Summary
    This summary is machine-generated.

    This review covers recent endothelin research, highlighting endothelin-2's roles in various systems and endothelin-1's cardiovascular implications, including sex differences.

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    Published on: January 23, 2019

    Area of Science:

    • Pharmacology
    • Endocrinology
    • Molecular Biology

    Background:

    • Reviews recent developments in endothelin (ET) research from the Twelfth International Conference on Endothelin (ET-12).
    • Focuses on the emerging roles of endothelin-2 in cardiovascular, reproductive, immune, and oncological systems.

    Discussion:

    • Examines endothelin's action on cardiac contractility and growth regulation.
    • Discusses the significant role of endothelin in renal disease pathogenesis.
    • Highlights epidemiological findings on sex differences in cardiovascular disease and endothelin-1 levels.

    Key Insights:

    • Endothelin-2 has diverse physiological and pathological roles.
    • Endothelin significantly impacts cardiovascular and renal systems.
    • Sex differences influence endothelin-1 responses and cardiovascular health.

    Outlook:

    • Explores epigenetic regulation of the endothelin pathway.
    • Reviews the silencing of the endothelin B receptor gene (EDNRB) in tumor development.
    • Suggests future research directions in endothelin signaling and its therapeutic potential.