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Related Experiment Videos

Changes in body protein composition following aortic reconstruction.

J P Fletcher1, B J Allen, N Blagojevic

  • 1Department of Surgery, University of Sydney, New South Wales, Australia.

The Australian and New Zealand Journal of Surgery
|March 1, 1990
PubMed
Summary

Major surgery causes significant body nitrogen loss, impacting muscle protein. Recovery to pre-operative nitrogen levels after aortic reconstruction can take over 90 days.

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Area of Science:

  • Biomedical Engineering
  • Surgical Metabolism
  • Nutritional Science

Background:

  • Major surgery triggers a significant neuroendocrine stress response.
  • This stress response leads to muscle protein catabolism and negative nitrogen balance.
  • Quantifying these metabolic changes is crucial for patient recovery.

Purpose of the Study:

  • To assess the impact of aortic reconstruction on total body nitrogen.
  • To determine the duration required for body nitrogen to return to pre-operative levels post-surgery.

Main Methods:

  • Utilized in vivo neutron activation analysis (IVNAA) to measure total body nitrogen.
  • Conducted 23 IVNAA studies across six patients undergoing aortic reconstruction.
  • Monitored body weight and nitrogen levels over an extended post-operative period.

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Main Results:

  • Aortic surgery resulted in a mean body weight decrease of 2.9%.
  • Total body nitrogen decreased significantly by a mean of 9.9%.
  • Only two out of six patients returned to pre-operative nitrogen values within the study's 92-day mean follow-up.

Conclusions:

  • Aortic reconstruction leads to substantial and prolonged depletion of total body nitrogen.
  • The neuroendocrine stress response significantly affects protein metabolism post-major surgery.
  • Extended recovery periods are indicated for restoring pre-operative nitrogen homeostasis after aortic surgery.