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Updated: May 15, 2026

Analyzing Murine Schwann Cell Development Along Growing Axons
Published on: November 21, 2012
Axonal regulation of Schwann cell ensheathment and myelination
1Department of Cell Biology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA. james.salzer@nyumc.org
Abstract:
Axons in the vertebrate peripheral nervous system are intimately associated with Schwann cells. Axons regulate the Schwann cell phenotype, determining whether they myelinate individual axons or ensheathe multiple, small axons in Remak bundles. Our current understanding of the axonal signals that drive Schwann cells towards these distinct morphological and phenotypic fates is briefly reviewed here. Elucidation of these signals, and the intracellular pathways they regulate, may lead to new, rational therapies for the treatment of inherited and acquired neuropathies.
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