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Published on: May 12, 2023
Long-term mortality following bloodstream infection
1Department of Infectious Diseases and Tropical Medicine, Hull and East Yorkshire Hospitals NHS Trust, Castle Hill Hospital, Cottingham, Hull, UK.
Summary
Bloodstream infections lead to significant long-term mortality, with age and low albumin as key predictors. High-risk patients may benefit from further follow-up to address modifiable factors.
Area of Science:
- Infectious Diseases
- Clinical Medicine
- Epidemiology
Background:
- Bloodstream infection (BSI) is linked to substantial short-term mortality.
- Long-term outcomes following BSI are less understood.
- Infection specialist consultation is crucial for patient management.
Purpose of the Study:
- To identify factors influencing mortality up to three years post-BSI.
- To analyze predictors of death at 30 days and 3 years after BSI.
- To inform long-term patient management strategies.
Main Methods:
- Retrospective cohort study of patients with BSI managed by an infectious diseases department.
- Analysis of clinical, laboratory, and demographic data.
- Cox regression models and Kaplan-Meier survival curves were used.
Main Results:
- 30-day mortality was 15%, and 3-year mortality reached 49%.
- Predictors of 30-day death included increasing age and low serum albumin.
- At 3 years, age, albumin, and vascular disease predicted mortality. Hypothermia and chronic renal disease were also significant predictors.
Conclusions:
- Mortality risk increases gradually after a BSI episode.
- Age and low albumin are consistent predictors of mortality at both 30 days and 3 years.
- Further follow-up and assessment of modifiable factors are recommended for high-risk patients.
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