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Related Concept Videos

Acute Pyelonephritis II: Diagnostic Studies and Management01:28

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Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
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Lactate in bitches with pyometra.

R Volpato1, L Rodello, R B Abibe

  • 1School of Veterinary Medicine and Animal Science, Sao Paulo State University, Botucatu, Brazil.

Reproduction in Domestic Animals = Zuchthygiene
|January 3, 2013
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Hyperlactataemia, indicated by elevated plasma lactate levels, is common in dogs with pyometra. This study found no significant difference in lactate concentrations between open and closed cervix pyometra cases.

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Area of Science:

  • Veterinary Medicine
  • Canine Health
  • Biochemistry

Background:

  • Pyometra is a common uterine disease in intact female dogs during the luteal phase.
  • Elevated plasma lactate (hyperlactataemia) is associated with poor prognosis in critically ill patients.
  • Lactate accumulation results from anaerobic glucose metabolism due to hypoxia or hypoperfusion.

Purpose of the Study:

  • To investigate plasma lactate concentrations in dogs diagnosed with pyometra.
  • To compare lactate levels between pyometra cases and healthy dogs.
  • To determine if cervix patency influences lactate levels in pyometra.

Main Methods:

  • Ultrasonography was used to diagnose pyometra in 31 female dogs.
  • Plasma lactate concentrations were measured using an enzymatic colorimetric method.
  • Lactate levels in pyometra cases were compared to established reference ranges for healthy dogs.

Main Results:

  • Dogs with pyometra exhibited significantly higher plasma lactate concentrations (mean ± SD: 3.55 ± 0.46 mm) compared to healthy dogs (0.3–2.5 mm).
  • Plasma lactate levels were similar in dogs with open cervix pyometra (3.54 ± 0.52 mm) and closed cervix pyometra (3.64 ± 1.03 mm).
  • The results indicate hyperlactataemia in canine pyometra, irrespective of cervix status.

Conclusions:

  • Elevated plasma lactate is a consistent finding in canine pyometra.
  • Cervix patency does not appear to influence plasma lactate concentrations in pyometra.
  • Plasma lactate measurement could serve as a potential biomarker for pyometra in dogs.