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Updated: May 15, 2026
13:08
Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
New developments in the area of factor XIII.
1University Clinic of Hematology and Central Hematology Laboratory, University Hospital and University of Bern, Bern, Switzerland. verena.schroeder@insel.ch
Journal of Thrombosis and Haemostasis : JTH
|January 3, 2013
Summary
Coagulation factor XIII (FXIII) is a multifunctional protein beyond blood clotting. Research reveals its diverse roles in wound healing, pregnancy, and other medical areas, highlighting its broad significance.
Area of Science:
- Biochemistry
- Hematology
- Cell Biology
Background:
- Coagulation factor XIII (FXIII) is primarily known for stabilizing fibrin clots.
- FXIII deficiency is linked to impaired wound healing and pregnancy maintenance.
- Recent research suggests FXIII possesses functions beyond hemostasis.
Purpose of the Study:
- To review novel findings on coagulation factor XIII (FXIII).
- To highlight the diverse functions of FXIII.
- To discuss potential clinical implications of FXIII's multifaceted roles.
Main Methods:
- Literature review of recent studies on FXIII.
- Analysis of research from diverse scientific backgrounds.
- Synthesis of information on FXIII's known and putative functions.
Main Results:
- FXIII acts as a transglutaminase, distinct from other serine proteases.
- FXIII is implicated in regulatory mechanisms, construction, and repair processes.
- Emerging evidence points to FXIII's involvement in various medical fields.
Conclusions:
- FXIII is a multifunctional protein with roles extending beyond hemostasis.
- Further research is required to elucidate FXIII's mechanisms and physiological relevance.
- Future clinical applications of FXIII's diverse functions are anticipated.
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