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Related Concept Videos

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Mechanism of Angiogenesis01:10

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Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...

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Related Experiment Video

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Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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Robustness in angiogenesis: notch and BMP shaping waves.

Karen Beets1, Danny Huylebroeck, Iván M Moya

  • 1Laboratory of Developmental Signaling, VIB Center for the Biology of Disease, VIB, 3000 Leuven, Belgium.

Trends in Genetics : TIG
|January 3, 2013
PubMed
Summary

Bone morphogenetic protein (BMP) signaling and Delta-like ligand 4 (DLL4)-Notch pathways interact to regulate blood vessel sprouting. This coregulation establishes tip-stalk cell boundaries, crucial for vascular patterning and potential therapeutic refinement.

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Last Updated: May 15, 2026

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Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Angiogenesis Research

Background:

  • Vascular patterning relies on endothelial cell (EC) communication for blood vessel sprouting.
  • Tip and stalk cell identities are dynamically regulated, notably by Notch signaling.

Purpose of the Study:

  • To review how bone morphogenetic protein (BMP) signaling coregulates Notch target genes in ECs.
  • To elucidate the interplay between DLL4-Notch and BMP signaling in vascular patterning.
  • To understand the molecular mechanisms driving tip-stalk cell boundary formation and EC plasticity.

Main Methods:

  • Review of recent studies on BMP and Notch signaling in endothelial cells.
  • Focus on the molecular interplay between DLL4-Notch and BMP effectors.
  • Analysis of gene expression dynamics related to tip-stalk cell differentiation.

Main Results:

  • BMP signaling acts as a coregulator of Notch target genes in ECs.
  • The combined action of DLL4-Notch and BMP signaling drives oscillatory gene expression.
  • This oscillatory expression is essential for maintaining sharp tip-stalk cell boundaries and a dynamic EC pool.

Conclusions:

  • The coregulation of Notch and BMP signaling is critical for vascular plasticity.
  • Understanding these molecular interactions can refine anti-angiogenesis and vessel normalization therapies.
  • Further research into vascular bed-specific plasticity may yield targeted therapeutic strategies.