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Updated: May 15, 2026

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation
Published on: November 10, 2023
DAS181 treatment of severe parainfluenza type 3 pneumonia in a lung transplant recipient
D R Drozd1, A P Limaye, R B Moss
1Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington 98195-6175, USA.
Abstract:
Parainfluenza virus (PIV) may cause life-threatening pneumonia in lung transplant patients and there are no proven effective therapies. We report the use of inhaled DAS181, a novel sialidase fusion protein, to treat severe PIV type 3 pneumonia in a lung transplant patient. Treatment was well tolerated and associated with improvement in oxygenation and symptoms, along with rapid clearance of PIV. DAS181 should be systematically evaluated for treatment of PIV infection in transplant recipients.
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