[Endophenotypes and autism spectrum disorders]
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Updated: May 15, 2026

Paradigms for Behavioral Assessment in Drosophila Model of Autism Spectrum Disorder
Published on: September 6, 2024
M Sokolowsky1, E Fakra, J-M Azorin
1Service de Pédopsychiatrie, Hôpital Sainte-Marguerite, 13274 Marseille cedex 9, France. michel.sokolwsky@ap-hm.fr
Abstract:
Genetic factors of ASD stay unknown after 30 years of research. The concept of "endophenotype" seems an interesting approach toward these factors. "Enlarged phenotypes" in families of ASD persons could lead to the definition of ASD endophenotypes. "Enlarged phenotypes" include clinical symptoms, morphological and functional brain anomalies enlightening ASD physiopathology and brain physiology. Knowledge of endophenotypes will lead to ASD genetic risk factors. This knowledge will open ethical questions about prenatal diagnosis.
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