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Updated: May 15, 2026

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
Published on: December 2, 2015
[Schizophrenia and/or bipolar disorder: the neurocognitive endophenotypes]
A Kaladjian1, J-M Azorin, P Pomietto
1Pôle de Psychiatrie des Adultes, CHU Robert Debré, Avenue du Général Koenig, Reims cedex, France. akaladjian@chu-reims.fr
Genetic research suggests schizophrenia and bipolar disorder share risks, not distinct categories. Neurocognitive functions may serve as shared endophenotypes, helping to understand these complex psychotic illnesses.
Area of Science:
- Psychiatry and Genetics
- Neuroscience and Behavioral Science
Context:
- The historical Kraepelinian dichotomy of psychosis into schizophrenic and affective disorders is challenged by modern research.
- Genetic studies indicate shared risk factors between schizophrenia and bipolar disorder, questioning their distinctness.
Purpose:
- To explore the utility of neurocognitive functions as endophenotypes for schizophrenia and bipolar disorder.
- To identify shared and illness-specific neurocognitive signatures across these psychotic disorders and their relatives.
Summary:
- Neurocognitive functions are influenced by genetic factors in both schizophrenia and bipolar disorder.
- Neuropsychological deficits are observed in unaffected relatives, suggesting a genetic link.
- This review comprehensively describes overlapping and unique neurocognitive endophenotypic patterns.
Impact:
- Provides a framework for understanding the genetic and neurobiological underpinnings of psychosis.
- Highlights the potential of neurocognitive endophenotypes to reduce phenotypic heterogeneity in genetic research.
- Informs future research directions for schizophrenia and bipolar disorder.
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