Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Infectious agents, immunity, and rheumatic diseases.

B D Schwartz1

  • 1Howard Hughes Medical Institute, St. Louis, Missouri.

Arthritis and Rheumatism
|April 1, 1990
PubMed
Summary

Hypotheses suggest infectious agents may trigger rheumatic diseases like ankylosing spondylitis (AS) and rheumatoid arthritis (RA). Further research is needed to confirm these links and understand the complex interplay between immunity and disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nonlinear transmission of picosecond 10.6-Mu m pulses in InSb.

Optics letters·2009
Same author

Safety of tacrolimus in patients with rheumatoid arthritis: long-term experience.

Rheumatology (Oxford, England)·2004
Same author

Carbon hydroxylation of alkyltetrahydropyranols: a paradigm for spiroacetal biosynthesis in Bactrocera sp.

Organic letters·2001
Same author

Neurophysiologic mechanisms of attention: a selective review of early information processing in schizophrenics.

Frontiers in bioscience : a journal and virtual library·2001
Same author

Neurophysiologic mechanisms of attention deficits in schizophrenia.

Neuropsychiatry, neuropsychology, and behavioral neurology·1999
Same author

Smooth pursuit tracking deficits of patients with schizophrenia at specific within-sine wave bins.

Neuropsychiatry, neuropsychology, and behavioral neurology·1999

Area of Science:

  • Immunology
  • Rheumatology
  • Infectious Diseases

Background:

  • Rheumatic diseases such as ankylosing spondylitis (AS) and rheumatoid arthritis (RA) have complex etiologies.
  • Genetic factors, like HLA-B27 for AS and HLA-DR4 for RA, are associated with these conditions.
  • The role of infectious agents in triggering or exacerbating rheumatic diseases remains an area of active investigation.

Purpose of the Study:

  • To propose hypotheses linking specific infectious agents to the development of AS and RA.
  • To provide a theoretical framework for understanding the interplay between infection, immunity, and rheumatic disease pathogenesis.
  • To guide future experimental research aimed at elucidating these complex relationships.

Main Methods:

  • The study presents hypothetical models based on existing suggestive, though not conclusive, data.
  • It discusses the association of HLA-B27 with AS and HLA-DR4 with RA.
  • The hypotheses are framed to be adaptable to account for exceptions, such as B27-negative AS and DR4-negative RA.

Main Results:

  • The presented hypotheses suggest potential mechanisms by which infectious agents could initiate or contribute to rheumatic diseases.
  • Acknowledges that current data is suggestive but not conclusive.
  • Recognizes that different mechanisms may be involved in different diseases or act in concert.

Conclusions:

  • The proposed hypotheses offer a foundational framework for future research into the etiology of rheumatic diseases.
  • Further experimental studies are necessary to validate or refute the proposed links between infectious agents, immune responses, and rheumatic conditions.
  • Understanding these relationships could lead to novel diagnostic or therapeutic strategies for AS, RA, and other related disorders.

Related Experiment Videos