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Updated: May 15, 2026

Preparation of Peripheral Blood Mononuclear Cell Pellets and Plasma from a Single Blood Draw at Clinical Trial Sites for Biomarker Analysis
Published on: March 20, 2021
Challenges and opportunities for oncology biomarker discovery
Avisek Deyati1, Erfan Younesi, Martin Hofmann-Apitius
1Knowledge Management, Merck Serono, 250 Frankfurterstrasse, Darmstadt 64293, Germany.
Abstract:
Recent success of companion diagnostics along with the increasing regulatory pressure for better identification of the target population has created an unprecedented incentive for drug discovery companies to invest in novel strategies for biomarker discovery. In parallel with the rapid advancement and clinical adoption of high-throughput technologies, a number of knowledge management and systems biology approaches have been developed to analyze an ever increasing collection of OMICs data. This review discusses current biomarker discovery technologies highlighting challenges and opportunities of knowledge capturing and presenting a perspective of the future integrative modeling approaches as an emerging trend in biomarker prediction.
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