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Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling
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Partial volume correction in arterial spin labeling using a Look-Locker sequence.

Jan Petr1, Georg Schramm, Frank Hofheinz

  • 1PET Center, Institute of Radiopharmacy, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.

Magnetic Resonance in Medicine
|January 3, 2013
PubMed
Summary
This summary is machine-generated.

A new method using Look-Locker EPI (LL-EPI) improves partial volume correction (PVC) for arterial spin labeling by generating partial volume (PV) maps. This approach reduces regression error by 12% compared to standard methods.

Keywords:
ASLarterial spin labelingcerebral blood flowlook-lockerpartial volume effect

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Area of Science:

  • Neuroimaging
  • Medical Physics

Background:

  • Partial volume (PV) effects, stemming from limited spatial resolution, significantly impact cerebral blood flow (CBF) investigations using arterial spin labeling (ASL).
  • Accurate partial volume correction (PVC) is crucial for reliable CBF quantification in ASL.
  • Current PVC methods rely on PV maps derived from segmented high-resolution T1-weighted images, which are prone to segmentation errors and coregistration inaccuracies with ASL images like echo-planar imaging (EPI).

Purpose of the Study:

  • To propose and evaluate an alternative method for generating partial volume (PV) maps for improved partial volume correction (PVC) in arterial spin labeling (ASL).
  • To assess the efficacy of a novel PV map generation technique using Look-Locker EPI (LL-EPI) acquisition.

Main Methods:

  • Utilized Look-Locker EPI (LL-EPI) acquisition to analyze the T1-recovery curve for subsequent partial volume (PV) map generation.
  • Evaluated the proposed method in a cohort of five healthy volunteers.

Main Results:

  • The novel method, when applied with a linear regression approach for partial volume correction (PVC), demonstrated a 12% reduction in regression error.
  • This indicates improved accuracy in the PVC process compared to conventional techniques.

Conclusions:

  • Partial volume (PV) map extraction directly from LL-EPI is a feasible and potentially superior alternative to traditional methods relying on segmented high-resolution T1-weighted images.
  • This technique offers a promising advancement for accurate cerebral blood flow quantification in ASL neuroimaging.