Targeting matrix metalloproteinases: design of a bifunctional inhibitor for presentation by tumour-associated galectins
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Updated: May 15, 2026

07:32
Bacterial Expression and Purification of Human Matrix Metalloproteinase-3 using Affinity Chromatography
Published on: March 30, 2022
Marco Bartoloni1, Blanca E Domínguez, Elisa Dragoni
1Department of Chemistry, University of Florence, Via della Lastruccia, 13 50019 Sesto F.no Firenze, Italy.
Chemistry (Weinheim an Der Bergstrasse, Germany)
|January 3, 2013
Abstract:
A new strategy to exploit galectin presence to target matrix metalloproteinases (MMPs) is presented. A bifunctional conjugate with lactose and an inhibitor for MMPs is able to bind MMP and Gal-3 simultaneously. This compound might allow the lectin to attract the MMP inhibitor to the tumour site and to block protumoural activities of the lectin at the same time.
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