Related Experiment Video
Updated: May 15, 2026

Quantitative Analysis of Dietary Vitamin A Metabolites in Murine Ocular and Non-Ocular Tissues Using High-Performance Liquid Chromatography
Published on: December 27, 2024
Retinoids: Potent regulators of metabolism
Pierre-Jacques Brun1, Kryscilla Jian Zhang Yang, Seung-Ah Lee
1Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Abstract:
Retinoids (vitamin A and its analogs) are highly potent regulators of cell differentiation, cell proliferation, and apoptosis. Because of these activities, retinoids have been most extensively studied in the contexts of embryonic development and of proliferative diseases, especially cancer and skin disease. Recently, there has been considerable new research interest focused on gaining understanding of the roles that retinoids and/or retinoid-related proteins may have in the development of metabolic diseases, primarily obesity, diabetes, and dyslipidemia. This review will summarize recent advances that have been made in these areas, focusing on the role of retinoids in modulating adipogenesis, the roles of retinoids and retinoid-related proteins as signaling molecules linking obesity with the development of type II diabetes, the roles of retinoids in pancreatic β-cell biology/insulin secretion, and the actions of retinoids in hepatic steatosis.
More Related Videos
Related Concept Videos
Regulation of Metabolism
Acne Infection
Transducer Mechanism: Nuclear Receptors
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
Phase I Reactions: Reductive Reactions
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
Pharmacokinetics in Pediatric Patients: Drug Metabolism

