Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab (Humira),...

Inflammatory Bowel Disease II: Ulcerative Colitis

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...

Inflammatory Bowel Disease III: Crohn's Disease

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel Disease...

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...

Inflammatory Bowel Disease II: Crohn's Disease

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Novel green synthesized agar/alginate biopolymer hydrogel-based magnetic composite beads for biomedical, environmental, and electrical applications.

RSC advances·2026

Same author

Dietary chlorogenic acid improves lipid metabolism through modulation of the gut-liver microbiota axis in hyperlipidemic mice.

Food & function·2026

Same author

Green synthesis and characterization of silver nanoparticles using <i>Asparagus officinalis</i> and their anti-inflammatory and antioxidant activities: <i>in silico</i>, <i>in vitro</i>, and <i>in vivo</i> studies.

Journal of drug targeting·2026

Same author

Fungal-mediated synthesis of silver nanoparticles using Porostereum spadiceum and their antioxidant, anti-inflammatory, and antidiabetic activities.

The international journal of biochemistry & cell biology·2026

Same author

Band gap energy shift as a biophysical marker of Puerarin's neuroprotective role in epilepsy-induced demyelination.

Journal of the Royal Society, Interface·2026

Same author

Recent Advances in Boswellic Acids as Anticancer Agents: Therapeutic Effects, SAR, and Computational Approaches.

Current topics in medicinal chemistry·2026

Search research articles

Related Experiment Video

Updated: May 15, 2026

Curcuminoid-Mediated Antimicrobial Photodynamic Therapy on a Murine Model of Oral Candidiasis

Curcuminoid-Mediated Antimicrobial Photodynamic Therapy on a Murine Model of Oral Candidiasis

Published on: October 27, 2023

Curcumin in inflammatory diseases.

Adeeb Shehzad¹, Gauhar Rehman, Young Sup Lee

¹School of Life Sciences, College of Natural Sciences, Kyungpook National University, Daegu 702-701, Korea.

Biofactors (Oxford, England)

|January 3, 2013

Summary

Curcumin, derived from turmeric, effectively combats inflammation by targeting multiple molecular pathways. This natural compound shows promise for preventing chronic inflammatory diseases and holds potential for clinical application.

More Related Videos

Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells

Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells

Published on: October 10, 2017

Related Experiment Videos

Last Updated: May 15, 2026

Curcuminoid-Mediated Antimicrobial Photodynamic Therapy on a Murine Model of Oral Candidiasis

Curcuminoid-Mediated Antimicrobial Photodynamic Therapy on a Murine Model of Oral Candidiasis

Published on: October 27, 2023

Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells

Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells

Published on: October 10, 2017

Area of Science:

Pharmacology
Molecular Biology
Immunology

Background:

Curcumin, a compound from turmeric, is recognized for its anti-inflammatory properties.
Inflammation is a key factor in numerous chronic diseases, including obesity, diabetes, arthritis, cardiovascular, and neurodegenerative disorders.
Ayurvedic medicine has historically used turmeric for inflammatory conditions.

Purpose of the Study:

To evaluate the anti-inflammatory effects of curcumin in the context of various chronic inflammatory diseases.
To explore the potential of curcumin as a preventative agent for inflammatory conditions.

Main Methods:

Review of in vitro and in vivo research on curcumin's anti-inflammatory mechanisms.
Analysis of clinical trial data regarding curcumin's efficacy.
Investigation of curcumin's molecular targets and pathways, including transcription factors, cytokines, and protein kinases.

Main Results:

Curcumin inhibits inflammatory cell proliferation, invasion, and angiogenesis.
It down-regulates key inflammatory mediators and enzymes.
Curcumin induces apoptosis via mitochondrial and receptor-mediated pathways, activating caspase cascades.
Curcumin is safe and non-toxic.

Conclusions:

Curcumin exhibits significant anti-inflammatory effects through diverse molecular mechanisms.
Pharmacological data supports curcumin's potential for preventing chronic inflammatory diseases.
There is a clear opportunity to translate curcumin into clinical practice for disease prevention.