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Ultrasound-guided Botulinum Toxin-A Injections: A Method of Treating Sialorrhea

Ultrasound-guided Botulinum Toxin-A Injections: A Method of Treating Sialorrhea

Published on: November 9, 2016

Volume matters: the influence of different botulinum toxin-A dilutions for sialorrhea in amyotrophic lateral

Evangelos Anagnostou¹, Anagnostou Evangelos, Michael Rentzos

¹Department of Neurology, University of Athens, Eginition Hospital, Vas. Sophias Avenue 74, 11528 Athens, Greece. granavan@yahoo.com

|January 3, 2013

Abstract

Introduction:

We aimed to determine the effect of different botulinum toxin-A (BTX-A) dilutions on the treatment efficacy and side effects for amyotrophic lateral sclerosis (ALS) related sialorrhea.

Methods:

Ten patients were enrolled in the study. BTX-A dilution for Group A was 100 U in 1 ml of saline, whereas the dilution for Group B was 100 U in 2 ml of saline. Both groups received 20 U of BTX-A in each parotid gland, and assessments were made by means of the Drooling Impact Scale, items 1 and 3 of the ALS functional rating scale, and visual analog scales for drooling and swallowing function.

Results:

Although both groups exhibited a similar improvement in drooling, Group B had a mild but significant deterioration in bulbar function that was not evident in Group A.

Conclusions:

These results suggest that BTX-A has a safer profile when reconstituted with 1 ml instead of 2 ml of saline.

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