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Chemerin and vaspin: possible targets to treat obesity?

Stephan Schultz1, Annette G Beck-Sickinger

  • 1Institute of Biochemistry, Faculty of Biosciences, Pharmacy and Psychology, Universität Leipzig, Brüderstrasse 34, 04103 Leipzig, Germany.

Chemmedchem
|January 3, 2013
PubMed

Insights

Obesity

Area of Science:

  • Biochemistry
  • Endocrinology
  • Molecular Biology

Background:

  • Obesity is a major global epidemic.
  • Obesity alters the expression of adipokines, bioactive molecules from fat tissue.
  • Adipokines influence adipose tissue, liver, and muscle metabolism.

Purpose of the Study:

  • To review novel adipokines, chemerin and vaspin, in obesity.
  • To explore their roles and therapeutic potential.
  • To identify new targets for obesity treatment.

Main Methods:

  • Literature review of current research on chemerin and vaspin.
  • Analysis of expression patterns and signal transduction.
  • Evaluation of impaired or protective actions in obesity.

Main Results:

  • Chemerin and vaspin exhibit altered expression in obesity.
  • Their functions impact metabolic health.
  • These adipokines show potential as therapeutic targets.

Conclusions:

  • Chemerin and vaspin are key players in obesity's molecular pathology.
  • Targeting these adipokines offers promising therapeutic strategies.
  • Further research could lead to novel obesity treatments.

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