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New approaches under development: cardiovascular embryology applied to heart disease

Karl Degenhardt1, Manvendra K Singh, Jonathan A Epstein

  • 1Division of Cardiology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

The Journal of Clinical Investigation
|January 3, 2013
PubMed

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Development of the Heart01:27

Development of the Heart

The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart tube by...