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Mass Spectrometry and Luminogenic-based Approaches to Characterize Phase I Metabolic Competency of In Vitro Cell Cultures
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Rapid screening for polymorphisms in dextromethorphan and mephenytoin metabolism

R J Guttendorf1, M Britto, R A Blouin

  • 1College of Pharmacy, University of Kentucky, Lexington 40536.

British Journal of Clinical Pharmacology
|April 1, 1990
PubMed
Summary

Coadministration of dextromethorphan and mephenytoin did not significantly alter their metabolic ratios in healthy volunteers. This study identified poor metabolizers for both drugs, aiding in understanding drug metabolism variations.

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