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Related Concept Videos

B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
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Autoimmune Disorders01:29

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
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Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Related Experiment Video

Updated: May 15, 2026

Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation
11:06

Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation

Published on: September 20, 2017

B-cell activating factor targeted therapy and lupus.

Alexis Boneparth1, Anne Davidson

  • 1Department of Pediatrics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

Arthritis Research & Therapy
|January 4, 2013
PubMed
Summary
This summary is machine-generated.

B-cell activating factor (BAFF) supports B cell development. Targeting BAFF with belimumab is a milestone for treating systemic lupus erythematosus (SLE), but its full clinical utility in autoimmune diseases requires further study.

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Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation
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The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
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Published on: November 1, 2015

Area of Science:

  • Immunology
  • Autoimmunity
  • Biologic Therapy

Background:

  • B-cell activating factor (BAFF) is a TNF-like cytokine crucial for B cell survival and differentiation.
  • Belimumab, a human antibody targeting soluble BAFF, represents a significant advance in biologic therapy for systemic lupus erythematosus (SLE).

Purpose of the Study:

  • To review BAFF's role in murine and human B cell development and maturation.
  • To summarize the clinical and mechanistic effects of BAFF inhibition in human SLE.

Main Methods:

  • Literature review of studies on BAFF in B cell biology.
  • Analysis of clinical trial data and mechanistic studies concerning BAFF inhibition in SLE.

Main Results:

  • BAFF plays a key role in B cell development and maturation across species.
  • BAFF inhibition demonstrates clinical efficacy in SLE, though mechanisms are still being elucidated.

Conclusions:

  • BAFF is a critical regulator of B cell homeostasis.
  • Targeting BAFF offers a promising therapeutic strategy for SLE and potentially other autoimmune conditions, warranting continued investigation.