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Updated: May 15, 2026
16:03
A Fish-feeding Laboratory Bioassay to Assess the Antipredatory Activity of Secondary Metabolites from the Tissues of Marine Organisms
Published on: January 11, 2015
Aaptamine derivatives from the Indonesian sponge Aaptos suberitoides
Cong-Dat Pham1, Rudolf Hartmann, Werner E G Müller
1Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, Universitaetsstrasse 1, 40225 Duesseldorf, Germany.
Journal of Natural Products
|January 4, 2013
Summary
Four new aaptamine derivatives were isolated from the Indonesian sponge Aaptos suberitoides. Some compounds, including aaptamine, demonstrated significant cytotoxic activity against lymphoma cells.
Area of Science:
- Marine natural products chemistry
- Pharmacology
- Chemical biology
Background:
- Marine sponges are a rich source of bioactive compounds.
- Aaptos suberitoides is known to produce aaptamine-type alkaloids.
- Exploring marine biodiversity for novel therapeutic agents is crucial.
Purpose of the Study:
- To isolate and characterize new aaptamine derivatives from Aaptos suberitoides.
- To evaluate the cytotoxic potential of isolated compounds against cancer cell lines.
Main Methods:
- Ethanol extraction of the sponge Aaptos suberitoides.
- Structure elucidation using one- and two-dimensional Nuclear Magnetic Resonance (NMR) spectroscopy.
- High-Resolution Electrospray Ionization Mass Spectrometry (HRESIMS) for structural confirmation.
- Cytotoxicity assays using the murine lymphoma L5178Y cell line.
Main Results:
- Four new aaptamine derivatives (compounds 1-4) were isolated, along with known compounds aaptamine (5) and related compounds (6-8).
- The structures were confirmed through comprehensive spectroscopic analyses (NMR, HRESIMS).
- Compounds 3, 5, and 6 exhibited cytotoxic activity, with IC(50) values between 0.9 and 8.3 μM against L5178Y cells.
Conclusions:
- The study successfully identified novel aaptamine derivatives from an Indonesian marine sponge.
- Aaptamine and its derivatives show promising cytotoxic effects, warranting further investigation as potential anti-cancer leads.
- This research highlights the potential of marine natural products in drug discovery.
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