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Enhanced intramucosal cytotoxic lymphocyte gene expression in ulcerative colitis

A C Stevens1, M L Lipman, J E Spivack

  • 1Inflammatory Bowel Disease Center, Department of Medicine, Divisions of Gastroenterology and Immunology, Beth Israel Hospital, Boston, Massachusetts, U.S.A.

Inflammatory Bowel Diseases
|January 4, 2013
PubMed
Summary

Cellular immune hyperactivity, specifically cytotoxic lymphocytes, is implicated in ulcerative colitis. This study found elevated granzyme B and perforin transcripts in ulcerative colitis lesions, suggesting increased cytotoxic lymphocyte activity.

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