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Updated: May 15, 2026

Competitive Homing Assays to Study Gut-tropic T Cell Migration
Published on: March 1, 2011
Pathological mechanisms of skin homing T cells in atopic dermatitis
Marta Ferran1, Luis F Santamaria-Babi
1From the 1Department of Dermatology, Hospital del Mar, IMAS-IMIM, Barcelona, Spain; and 2Institute for Research in Biomedicine, University of Barcelona, Barcelona, Spain.
Abstract:
Skin infiltration of circulating memory T cells with cutaneous tropism is considered one of the pathologic mechanisms in atopic dermatitis (AD). Skin-seeking circulating T lymphocytes can be identified by their expression of the cutaneous lymphocyte-associated antigen on the cell surface. Recent studies have contributed useful new information about the function and recirculation properties of those cells in AD patients. This review integrates the latest findings on peripheral cutaneous lymphocyte-associated antigen memory T cells in AD and highlights the relevance of this cell type and its importance to our understanding of the pathologic mechanisms of AD.
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