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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...

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Related Experiment Video

Updated: May 15, 2026

Lung microRNA Profiling Across the Estrous Cycle in Ozone-exposed Mice
07:07

Lung microRNA Profiling Across the Estrous Cycle in Ozone-exposed Mice

Published on: January 7, 2019

Regulating the Regulators: microRNA and Asthma.

Jia-Wang Wang1, Kunyu Li, Gary Hellermann

  • 1Department of Internal Medicine Division of Translational Medicine and Nanomedicine Research Center1, and Division of Allergy and Immunology2, Department of Molecular Medicine3, University of South Florida College of Medicine, and James A. Haley VA Hospital and Medical Research Center4, Tampa, FL 33612.

The World Allergy Organization Journal
|January 4, 2013
PubMed
Summary

Understanding the fundamental causes of asthma is crucial for developing effective treatments. MicroRNAs (miRNAs) are key epigenetic regulators involved in asthma pathogenesis and may offer diagnostic and therapeutic potential.

Related Experiment Videos

Last Updated: May 15, 2026

Lung microRNA Profiling Across the Estrous Cycle in Ozone-exposed Mice
07:07

Lung microRNA Profiling Across the Estrous Cycle in Ozone-exposed Mice

Published on: January 7, 2019

Area of Science:

  • Immunology
  • Genetics
  • Respiratory Medicine

Background:

  • Asthma is a chronic, T-helper 2 (TH2) immune-mediated inflammatory disease.
  • The precise causes of asthma remain incompletely understood, hindering therapeutic development.
  • Epigenetic modifications, including microRNA (miRNA) dysregulation, are implicated in TH2 responses and asthma.

Purpose of the Study:

  • To explore the role of microRNAs in asthma pathogenesis.
  • To investigate the potential of circulating miRNAs for asthma diagnosis.
  • To identify miRNA-based therapeutic strategies for asthma.

Main Methods:

  • Review of current literature on asthma, TH2 immunity, and epigenetic regulation.
  • Analysis of the role of microRNAs as key epigenetic regulators.
  • Discussion of the diagnostic potential of circulating miRNA profiling.
  • Exploration of miRNA network defects in asthma pathogenesis.

Main Results:

  • MicroRNAs are critical epigenetic regulators of gene expression.
  • Dysregulation of miRNAs is strongly associated with asthma pathogenesis.
  • Circulating miRNA profiling shows high specificity and sensitivity for asthma diagnosis.
  • Targeting miRNA regulation networks presents a promising therapeutic avenue.

Conclusions:

  • MicroRNAs play a significant role in the initiation and maintenance of asthma.
  • Circulating miRNAs hold potential as reliable biomarkers for asthma diagnosis.
  • Modulating miRNA networks offers a novel therapeutic strategy for asthma treatment.