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Updated: May 15, 2026

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Microfluidic impedance cytometer for platelet analysis.

Mikael Evander1, Antonio J Ricco, John Morser

  • 1Dept. of Measurement Technology and Industrial Electrical Engineering, Lund University, Sweden. mikael.evander@elmat.lth.se

Lab on a Chip
|January 4, 2013
PubMed
Summary
This summary is machine-generated.

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This study introduces a microfluidic impedance cytometer for platelet analysis. The device accurately measures platelet activation using multi-frequency impedance spectroscopy, offering a reliable diagnostic tool.

Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Hematology

Background:

  • Platelet activation is crucial in thrombosis and hemostasis.
  • Accurate and rapid measurement of platelet activation is clinically significant.
  • Existing methods for platelet analysis can be complex or time-consuming.

Purpose of the Study:

  • To design and characterize a microfluidic impedance cytometer for platelet analysis.
  • To evaluate the platform's ability to distinguish between resting and activated platelets.
  • To assess the impact of the microfluidic system on platelet viability.

Main Methods:

  • Utilized dielectrophoretic focusing for cell centering in a two-phase flow.
  • Employed differential impedance spectroscopy across multiple frequencies (280 kHz to 4 MHz).

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Last Updated: May 15, 2026

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
10:25

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

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  • Validated results using flow cytometry to assess platelet activation and shear stress effects.

    • Main Results:

    • The microfluidic impedance cytometer successfully distinguished platelets from erythrocytes using single-frequency measurements.
    • Multi-frequency impedance measurements and discriminant analysis differentiated resting from activated platelets.
    • No significant change in platelet activation was observed after passage through the microfluidic chip.

    Conclusions:

    • The developed microfluidic impedance cytometer provides a sensitive and reliable method for assessing platelet activation.
    • The platform enhances signal-to-noise ratio while minimizing shear forces on cells.
    • This technology enables the ready determination of platelet activation status in blood samples.