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Related Experiment Video

Updated: May 15, 2026

Detection of Antibodies That Neutralize the Cellular Uptake of Enzyme Replacement Therapies with a Cell-based Assay

Detection of Antibodies That Neutralize the Cellular Uptake of Enzyme Replacement Therapies with a Cell-based Assay

Published on: September 10, 2018

Anti-immunoglobulin e therapy.

Manav Segal¹, Jeffrey R Stokes, Thomas B Casale

¹From the Division of Allergy and Immunology, Department of Medicine, Creighton University School of Medicine, Omaha, NE.

The World Allergy Organization Journal

|January 4, 2013

Summary

This summary is machine-generated.

Immunoglobulin E (IgE) plays a key role in allergic diseases. Anti-IgE therapy, like omalizumab, effectively reduces IgE levels and inflammation, offering a new treatment for conditions such as asthma.

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Detection of Antibodies That Neutralize the Cellular Uptake of Enzyme Replacement Therapies with a Cell-based Assay

Detection of Antibodies That Neutralize the Cellular Uptake of Enzyme Replacement Therapies with a Cell-based Assay

Published on: September 10, 2018

Generation of Recombinant Human IgG Monoclonal Antibodies from Immortalized Sorted B Cells

Generation of Recombinant Human IgG Monoclonal Antibodies from Immortalized Sorted B Cells

Published on: June 5, 2015

Area of Science:

Immunology
Allergology
Pharmacology

Background:

Immunoglobulin E (IgE) is central to atopic disorders including asthma and allergic rhinitis.
Elevated serum IgE and allergen-specific IgE are hallmarks of atopic conditions.
Humanized monoclonal anti-IgE antibodies offer novel therapeutic strategies.

Purpose of the Study:

To review the mechanisms of action of anti-IgE therapy.
To evaluate the efficacy of anti-IgE therapy in allergic diseases, particularly asthma.
To discuss dosing and safety considerations for omalizumab.

Main Methods:

Review of existing literature on anti-IgE therapy.
Analysis of omalizumab's binding to the Fc portion of IgE.
Examination of omalizumab's impact on IgE levels and inflammatory cells.

Main Results:

Omalizumab rapidly and significantly reduces free serum IgE.
Anti-IgE therapy impacts inflammatory cell activity involved in allergic responses.
Clinical studies demonstrate the utility of anti-IgE therapy in asthma and allergic rhinitis.

Conclusions:

Anti-IgE therapy, exemplified by omalizumab, provides a valuable treatment modality for allergic diseases.
Understanding IgE's role is crucial for developing targeted therapies.
Further research into dosing and safety ensures optimal patient outcomes.