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Updated: May 15, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
Deadly ibd
1The University of New Mexico and The Department of Veterans Affairs Medical Center Albuquerque, New Mexico, U.S.A.
Insights
This population-based cohort study found that individuals with inflammatory bowel disease (IBD) have a slightly increased risk of mortality. However, IBD does not significantly increase the risk of death from specific causes like cancer or cardiovascular disease.
Area of Science:
- Gastroenterology
- Epidemiology
- Public Health
Background:
- Inflammatory Bowel Disease (IBD) encompasses Crohn's disease and ulcerative colitis.
- Understanding long-term survival and mortality patterns in IBD is crucial for patient care and public health.
- Previous studies have yielded conflicting results regarding IBD's impact on overall and cause-specific mortality.
Purpose of the Study:
- To investigate the survival rates of patients diagnosed with IBD.
- To determine if IBD increases the risk of death from specific causes.
- To analyze mortality trends in a large, population-based cohort.
Main Methods:
- A population-based cohort study design was employed.
- Data were collected from a defined geographical region, ensuring representativeness.
- Survival analysis techniques were used to compare mortality in IBD patients versus the general population.
Main Results:
- Patients with IBD exhibited a slightly elevated overall mortality risk compared to the general population.
- No significant increase in cause-specific mortality was observed for major causes such as cancer or cardiovascular disease.
- The findings suggest that while IBD impacts longevity, it may not be a primary driver of death from other common diseases.
Conclusions:
- IBD is associated with a modest increase in overall mortality.
- The study provides reassurance regarding the absence of significantly elevated risks for major cause-specific mortality in IBD patients.
- These findings have implications for clinical management and patient counseling regarding prognosis.
Abstract:
Survival and Cause-Specific Mortality in Inflammatory Bowel Disease: A Population-Based Cohort Study. Persson PG, Bernell O, Leijonmarck CE, Farahmand BY, Hellers G, Ahlbom A. Gastroenterology 1996;110:1339-45.
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