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Visualization of Estrogen Receptors in Colons of Mice with TNBS-Induced Crohn's Disease using Immunofluorescence

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Sialyl-tn antigen expression in Crohn's colitis.

A Ta¹, N Harpaz, C Bodian

¹Gastrointestinal Research Laboratory, Department of Medicine, and Departments of *Pathology and †Biomathematical Sciences, Mount Sinai School of Medicine, New York, New York, U.S.A.

Inflammatory Bowel Diseases

|January 4, 2013

Summary

Sialyl-Tn (STn) antigen expression is linked to colon cancer progression. In Crohn's colitis, STn is found in 40% of specimens, particularly in the left colon and during active inflammation, suggesting differences from ulcerative colitis.

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Area of Science:

Gastroenterology
Oncology
Immunohistochemistry

Background:

The mucin-associated sialyl-Tn (STn) antigen is a known biomarker for malignant progression in colon cancer.
Previous studies show STn expression increases in ulcerative colitis (UC) patients who develop colon cancer, often years before dysplasia detection.

Purpose of the Study:

To systematically examine STn antigen expression in Crohn's colitis, a condition not previously studied in this context.
To compare STn expression patterns in Crohn's colitis with those observed in UC.

Main Methods:

Immunohistochemical staining using monoclonal antibody TKH2 was performed on 110 surgical specimens from 59 patients with Crohn's colitis or ileocolitis.
Analysis focused on the presence and location of STn antigen expression in relation to disease characteristics.

Main Results:

The STn antigen was expressed in 40% of Crohn's colitis specimens.
STn expression was more prevalent in left colon specimens, irrespective of disease extent (segmental or pancolitis).
Active inflammation was associated with increased STn expression, regardless of location or disease pattern.

Conclusions:

STn antigen expression is a notable feature in Crohn's colitis.
The enhanced STn expression in Crohn's colitis compared to UC may indicate distinct underlying inflammatory mechanisms and cytokine profiles.