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Updated: May 15, 2026

A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s
Published on: September 25, 2017
Reply to "A further study of acetylacetone nitrosation"
Luis García-Río1, Mercedes Parajó, Moisés Pérez-Lorenzo
1Centre for Research in Biological Chemistry and Molecular Materials, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain. luis.garcia@usc.es
This study refutes Iglesias et al.’s critique of acetylacetone nitrosation mechanisms. Additional evidence confirms the originally proposed reaction pathway, highlighting experimental errors in the critique.
Area of Science:
- Organic Chemistry
- Reaction Mechanisms
Background:
- Critique of acetylacetone nitrosation mechanism by Iglesias et al.
- Discussion of experimental errors and neglected factors in the critique.
Discussion:
- Analysis of inconsistencies in Iglesias et al.'s experimental data.
- Identification of critical factors overlooked by Iglesias et al.
Key Insights:
- The originally proposed mechanism for acetylacetone nitrosation is supported by additional evidence.
- Iglesias et al.'s alternative mechanism is shown to be unsubstantiated.
Outlook:
- Further research into nitrosation reactions.
- Clarification of reaction pathways in organic chemistry.
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