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[Cell-mediated cytotoxicity against Rous sarcoma in the hamster (author's transl)]
The cytotoxic response of lymphoid cells from hamsters immunized against RS 2/3 cells, transformed by Rous sarcoma virus, was investigated. The highest cytotoxic response was obtained after the third inoculation of RS 2/3 cells. Both the non-tumor-bearing hamsters immunized with physically or chemically treated RS 2/3 cells and the tumor-bearing hamsters, grafted with live RS 2/3 cells provided splenic cytotoxic lymphoid cells. On the contrary, lymphoid cells obtained from lymph nodes were only slightly cytotoxic. The results did not permit to establish a relationship between the cytotoxic activity of the lymphoid cells obtained from the spleen and from the lymph nodes. The cytotoxic response of lymphoid cells in vitro was not correlated with tumor rejection, in vivo.
The cytotoxic response of lymphoid cells from hamsters immunized against RS 2/3 cells, transformed by Rous sarcoma virus, was investigated. The highest cytotoxic response was obtained after the third inoculation of RS 2/3 cells. Both the non-tumor-bearing hamsters immunized with physically or chemically treated RS 2/3 cells and the tumor-bearing hamsters, grafted with live RS 2/3 cells provided splenic cytotoxic lymphoid cells. On the contrary, lymphoid cells obtained from lymph nodes were only slightly cytotoxic. The results did not permit to establish a relationship between the cytotoxic activity of the lymphoid cells obtained from the spleen and from the lymph nodes. The cytotoxic response of lymphoid cells in vitro was not correlated with tumor rejection, in vivo.