Related Experiment Video
Updated: May 15, 2026

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
Published on: November 9, 2016
Cryotherapeutic topical analgesics for pediatric intravenous catheter placement: ice versus vapocoolant spray
Marie R Waterhouse1, Deborah R Liu, Vincent J Wang
1Division of Emergency Medicine, Department of Pediatrics, Children's Hospital Los Angeles, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90027, USA. mwaterhouse@chla.usc.edu
Insights
Vapocoolant spray may be more effective than ice packs for reducing pain during intravenous catheter insertion in children. Patients reported higher satisfaction with the spray, and it did not affect successful IV placement rates.
Area of Science:
- Pediatric Emergency Medicine
- Pain Management
- Cryotherapy
Background:
- Intravenous catheter placement is a common cause of pain for hospitalized children.
- Effective pain relief methods are crucial for pediatric patient comfort and procedural success.
Purpose of the Study:
- To compare the efficacy of vapocoolant spray versus topical ice packs for pain reduction during intravenous catheter insertion in pediatric patients.
- To assess patient satisfaction with each cryotherapeutic method.
Main Methods:
- A prospective study enrolled 95 pediatric patients (aged 9-18 years) requiring IV catheter placement.
- Participants were randomized to receive either vapocoolant spray or a topical ice pack for 3 minutes prior to IV insertion.
- Pain levels were assessed using Visual Analog Scale (VAS) scores at baseline, post-treatment, and during IV insertion, with physician assessments also recorded.
Main Results:
- While median VAS scores were similar, the change in VAS from baseline was greater with vapocoolant spray, suggesting higher efficacy.
- A higher percentage of patients in the vapocoolant spray group (76%) reported their treatment worked well compared to the ice pack group (49%).
- Physician-assessed pain scores were lower and less variable than patient-reported scores. Successful IV insertion rates were high (83%) for both groups.
Conclusions:
- Vapocoolant spray appears to be a more effective analgesic than ice packs for pediatric IV insertion.
- Patient satisfaction was higher with vapocoolant spray.
- Neither cryotherapeutic method negatively impacted the success rate of IV catheter placement.
Objectives:
Intravenous catheter placement is one of the most common sources of pain for children in inpatient settings. We sought to compare the efficacy of 2 cryotherapeutic treatments for this procedure: vapocoolant spray versus topical ice pack.
Methods:
We prospectively enrolled 95 patients, aged 9 to 18 years, in a pediatric emergency department who required intravenous (IV) catheters as part of their treatment. Subjects were randomly assigned to receive vapocoolant spray or topical ice pack for 3 minutes, before IV catheter placement. Subjects completed visual analog scale (VAS) scores for 3 time points: baseline, pretreatment with ice or spray, and IV insertion. The principal investigator and 2 physicians viewing video recordings of the procedure also completed VAS scores for observed pain levels. Visual analog scale scores were compared using the Wilcoxon rank sum test.
Results:
Although median VAS scores were similar, the change in VAS from baseline was of greater magnitude in the Painease group, indicating that it may be more effective. More subjects in the Painease group (76%) felt their treatment worked well, compared with 49% in the ice group. Physician-assigned VAS scores were lower and less variable than those of subjects. Most IV insertions were successful (83%).
Conclusions:
Vapocoolant spray may be more effective than ice as an analgesic for IV insertion. Subjects were more satisfied with vapocoolant spray. Neither agent caused a decrease in successful IV insertion rates.
Related Concept Videos
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia
One of the advantages of...
Local Anesthetics: Common Agents and Their Applications
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia
Parenteral Anesthetics: Overview
Local Anesthetics: Clinical Application as Epidural Anesthesia
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Local Anesthetics: Clinical Application as Spinal Anesthesia

