Related Experiment Video
Updated: May 15, 2026

The Utilization of Oropharyngeal Intratracheal PAMP Administration and Bronchoalveolar Lavage to Evaluate the Host Immune Response in Mice
Published on: April 2, 2014
Update on the Pathogenic Mechanisms of Isocyanate-induced Asthma
Gyu-Young Hur1, Sung-Jin Choi, Seung-Youp Shin
1From the *Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon; †Department of Otolaryngology, College of Medicine, KyungHee University, Seoul; and ‡Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
Background:
: The pathogenic mechanisms of toluene diisocyanate (TDI)-induced asthma are not understood clearly.
Methods:
: In this review, we summarized recent data to further understand the pathogenic mechanisms through recent approach of molecular genetic studies, and specific antibody responses to cellular mechanisms.
Results:
: Genetic polymorphism studies suggested the involvement of oxidant/antioxidant-related genes and neurogenic inflammatory response genes. A high-resolution technique of HLA allele suggested some HLA genetic markers presenting the phenotype of TDI-induced asthma. The new volatile type of TDI-human serum albumin conjugate could improve specific immunoglobulin E and immunoglobulin G bindings in enzyme-linked immunosorbent assay studies for identifying TDI-induced asthma patients. The role of bronchial epithelial cells and cytokeratins derived from epithelial cells could be involved in autoantibody productions, suggesting that an autoimmune mechanism may be involved in airway inflammation. Neutrophil activation and oxidant/antioxidant-related mechanisms were also suggested.
Conclusion:
: The pathogenic mechanism of TDI-induced asthma is complicated as various humoral and cellular mechanisms are combined and involved differently on an individual basis. Therefore, additional efforts for further elucidation should follow.
Related Concept Videos
Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-II: Pathophysiology and Classification
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma I: Introduction
Asthma-I: Introduction
Asthma III: Clinical Manifestations
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
