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FoxP2 regulates neurogenesis during embryonic cortical development.

David Tsui1, John P Vessey, Hideaki Tomita

  • 1Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Canada M5G 1L7.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|January 4, 2013
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Summary

The transcription factor FoxP2 regulates neural precursor development in the mammalian cortex. This finding offers insights into the molecular basis of human speech evolution and cortical development.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Genetics

Background:

  • The transcription factor FoxP2 is linked to human speech development, but its cellular functions remain largely unknown.
  • The mammalian cortex is crucial for speech, and understanding its development is key to understanding speech evolution.

Purpose of the Study:

  • To investigate the cellular function of FoxP2 in mammalian cortical development.
  • To elucidate the role of FoxP2 in neurogenesis and progenitor cell transitions.

Main Methods:

  • Knockdown of FoxP2 in embryonic cortical precursors.
  • Overexpression of human and mouse FoxP2, including a human mutant form.
  • Analysis of neurogenesis and intermediate progenitor cell generation.

Main Results:

  • FoxP2 knockdown inhibited neurogenesis by impeding the transition from radial glial precursors to intermediate progenitors.
  • Overexpression of human FoxP2 enhanced intermediate progenitor and neuron genesis, while a human mutant form decreased it.
  • Human FoxP2 acted as a gain-of-function protein, and the mutant acted as a dominant-inhibitory protein in the murine system.

Conclusions:

  • FoxP2 regulates the critical transition from neural precursors to transit-amplifying progenitors and neurons.
  • These findings shed light on molecular mechanisms underlying mammalian cortical evolution and the development of speech.