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Related Concept Videos

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
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Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
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Related Experiment Video

Updated: May 15, 2026

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

Halting the allergic march.

Hugo P Van Bever1, Sudesh T Samuel, Bee Wah Lee

  • 1From the Department of Pediatrics, National University Singapore, Singapore.

The World Allergy Organization Journal
|January 4, 2013
PubMed
Summary
This summary is machine-generated.

Childhood allergic diseases like asthma are rising globally. Research suggests reduced early-life bacterial exposure may contribute, alongside genetics and environment, to these conditions.

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Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

Related Experiment Videos

Last Updated: May 15, 2026

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

Area of Science:

  • Allergy and immunology
  • Pediatric health
  • Environmental medicine

Background:

  • Childhood allergic diseases (asthma, rhinitis, atopic dermatitis) show a significant global increase.
  • In Singapore, asthma prevalence exceeds 20%, with 50% of children exhibiting allergy indicators.
  • Reduced early-life bacterial exposure is a potential factor in rising allergy rates, interacting with genetic and environmental influences.

Purpose of the Study:

  • To review current understanding of allergic sensitization, from prenatal to postnatal stages.
  • To explore the mechanisms behind the "allergic march" phenomenon.
  • To discuss prevention and treatment strategies for allergic diseases.

Main Methods:

  • Literature review of allergic sensitization.
  • Analysis of "allergic march" mechanisms.
  • Review of therapeutic interventions, including probiotics and immunotherapy.

Main Results:

  • Allergic sensitization occurs both prenatally and postnatally.
  • The "allergic march" involves a progression of allergic conditions.
  • Bacterial products (probiotics, prebiotics, synbiotics) and immunotherapy show potential in managing allergies.

Conclusions:

  • Allergic disease development is multifactorial, involving genetics and environment.
  • Understanding allergic sensitization and the "allergic march" is crucial for management.
  • Probiotics, prebiotics, synbiotics, and immunotherapy offer promising avenues for prevention and treatment.