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The evolutionary role of the IL-33/ST2 system in host immune defence
Susanne Sattler1, Hermelijn H Smits, Damo Xu
1Department of Medicine, Centre for Complement and Inflammation Research, Imperial College London, Hammersmith Campus, Du Cane Road, W12 0NN London, UK. s.sattler@imperial.ac.uk
Abstract:
Interleukin (IL)-33 is a recently identified pleiotropic cytokine, which can orchestrate complex innate and adaptive immune responses in immunity and disease. It has been characterized as a cytokine of the IL-1 family and affects a wide range of immune cells by signalling through its receptor ST2L. Accumulating evidence suggests a crucial role of IL-33/ST2 in inducing and modifying host immune responses against a variety of pathogens including parasites, bacteria, viruses and fungi as well as sterile insults of both endogenous and exogenous source. In this review, we endeavour to give a comprehensive overview of the current knowledge about the role of IL-33 and its receptor ST2 in host defence against infections.
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