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Acute lymphoblastic leukaemia presenting with galactorrhoea.
Wing Shan Queenie See1, Daniel Ka Leung Cheuk, Kong Lam Marcus Fung
1Department of Paediatrics & Adolescent Medicine, The University of Hong Kong, Hong Kong, Hong Kong.
BMJ Case Reports
|January 4, 2013
Summary
A teenage girl with galactorrhoea was diagnosed with acute lymphoblastic leukaemia. Ectopic prolactin production, indicated by prolactin mRNA, resolved with leukaemia remission, resolving galactorrhoea.
Area of Science:
- Endocrinology
- Oncology
- Molecular Biology
Background:
- Hyperprolactinaemia can manifest with galactorrhoea.
- Acute lymphoblastic leukaemia (ALL) is a common childhood cancer.
- Ectopic hormone production is a rare complication of malignancies.
Observation:
- A teenage girl presented with galactorrhoea and moderate hyperprolactinaemia.
- She was diagnosed with acute lymphoblastic leukaemia (ALL).
Findings:
- Further investigations revealed prolactin messenger RNA (mRNA) in the patient's bone marrow.
- This finding supported ectopic prolactin production.
- Both ectopic prolactin mRNA and galactorrhoea resolved upon achieving disease remission after ALL treatment.
Implications:
- This case highlights a rare association between acute lymphoblastic leukaemia and ectopic prolactin production.
- Resolution of ectopic hormone production with cancer remission suggests a direct link.
- Understanding such paraneoplastic syndromes is crucial for comprehensive patient management.
