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Published on: October 26, 2016
Application of dual cyclodextrin systems in capillary electrophoresis enantioseparations
Anne-Catherine Servais1, Marianne Fillet
1Department of Pharmaceutical Sciences, University of Liège, Liège, Belgium. acservais@ulg.ac.be
Abstract:
The enantioseparation of acidic and neutral compounds can be successfully achieved in capillary electrophoresis (CE) using dual cyclodextrin (CD) systems. This chapter describes how to separate the enantiomers of acidic or neutral substances using dual CD systems made up of a negatively charged CD derivative, i.e., sulfobutyl-β-CD (SB-β-CD) or carboxymethyl-β-CD (CM-β-CD), in combination with a neutral one, namely, heptakis(2,3,6-tri-O-methyl)-β-CD (TM-β-CD). An acidic compound (carprofen) and a weakly acidic drug (pentobarbital) were selected as model compounds.
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