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Published on: April 5, 2019
Polysaccharide-derived chiral stationary phases in capillary electrochromatography enantioseparations
Zhenbin Zhang1, Hanfa Zou, Junjie Ou
1National Chromatographic R&A Center, Dalian Institute of Chemical Physics, Dalian, China.
Abstract:
Capillary electrochromatography (CEC) has been shown to be a promising technique for miniaturized enantioseparations. Here we present the preparation and application of positively charged cellulose derivative-based chiral stationary phases (CSPs) for the CEC separation of enantiomers. The cellulose derivatives were chemically immobilized onto diethylenetriaminopropylated silica gel using tolylene-2,4-diisocyanate as a spacer. The separation of enantiomers in CEC can be performed on the positively charged CSPs with nonaqueous and aqueous mobile phases.
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